Platelet count can be altered in various diseases and treatments and measuring it may provide better insight into the expected outcome. So far, quantification of platelet count is done within laboratory conditions by using established hematology analyzer equipment. Outside clinical laboratories point-of-care devices could offer a more practical solution that can be executed without extensive training, cleaning or maintenance.
Precise measurement of platelets in low and high concentrations
The precise assessment of the platelet count in whole blood is crucial in clinical hematology as low platelet count may lead to bleeding complications. The normal platelet count is widely determined as 150-400 x 109/L in whole blood and its aberrations have been associated not only with hemostatic and thrombotic diseases but also with cancer and chronic inflammatory diseases. Overall data & various publications suggest that platelet count might be a possible biomarker or prognostic marker for various diseases.
Hematology analyzer equipment typically used in controlled laboratory conditions
Currently, there are various automated methods available for determination of platelet counts, with the majority mainly performed in controlled laboratory conditions. Moreover, several point-of-care (POC) hematology analyzers have been tested in research and clinical settings providing complete blood cell (CBC) measurements including platelet counts.
Hematology analyzers focus on whole blood samples. Not on concentrated PRP.
However, these hematology analyzers are focused on whole blood samples, and not on platelet rich plasma (PRP) samples which may contain an extreme high platelet count. In regenerative medicine, PRP with a tremendous number of platelets can be used and hence a reliable platelet counter with the capability of measuring these extreme platelet counts would be favorable.
The PC100 point of care automated platelet counter
The PC100 automated platelet counter has been developed with the intended use as a point-of-care device outside of laboratories for measuring platelet count at both the lower and higher ranges. The PC100 is an optical platelet counter using a patented optical technique that enables the precise quantification of platelets, both at an extremely high and extremely low concentrations.
PC100 versus other hematology analyzers
Together with the Cardiovascular Research Institute Maastricht (CARIM) of Maastricht University Medical Centre+, in the Netherlands departments of Biochemistry and Internal Medicine we evaluated the analytical and clinical performance of the PC100 automated platelet counter for platelet counts in whole blood and platelet count in platelet rich plasma (PRP). Main conclusion of this research is that the PC100 platelet counter can be used interchangeably with commercial hematology analyzers for determining platelet counts as it also provides reliable and accurate results. The strength of the PC100 is that it combines fast and accurate platelet count results with an easy procedure that can be executed with limited training without extensive maintenance or cleaning.